Comparative respiratory system mechanics in rodents

Comparative respiratory system mechanics in rodents.

Because of the wide utilization of rodents as animal models in respiratory research and the limited data on measurements of respiratory input impedance (Zrs) in small animals, we measured Zrs between 0.25 and 9.125 Hz at different levels (0-7 hPa) of positive end-expiratory pressure (PEEP) in mice, rats, guinea pigs, and rabbits using a computer-controlled small-animal ventilator (Schuessler TF...

Differential Consequences of Unilateral Nasal Air-Puff Stimulation on Breathing Pattern and Respiratory System Mechanics in Tracheotomized Rats

Respiratory mechanics in anaesthesia.

The present knowledge of respiratory mechanics in anaesthetized humans is astonishingly scanty. This probably reflects the notion that measurement of the mechanics of ventilation during anaesthesia is difficult to perform. In fact, in mechanically ventilated anaesthetized-paralysed humans, a detailed analysis of respiratory mechanics can be performed readily with simple and commonly available e...

Respiratory system mechanics in sedated, paralyzed, morbidly obese patients.

The effects of inspiratory flow and inflation volume on the mechanical properties of the respiratory system in eight sedated and paralyzed postoperative morbidly obese patients (aged 37.6 +/- 11.8 yr who had never smoked and had normal preoperative seated spirometry) were investigated by using the technique of rapid airway occlusion during constant-flow inflation. With the patients in the supin...

Mathematical modeling of respiratory system mechanics in the newborn lamb.

In this paper, a mathematical model of the respiratory mechanics is used to reproduce experimental signal waveforms acquired from three newborn lambs. As the main challenge is to determine specific lamb parameters, a sensitivity analysis has been realized to find the most influent parameters, which are identified using an evolutionary algorithm. Results show a close match between experimental a...